The Leading Causes of Death in Indiana for 2025 Revealed

New data has revealed the leading causes of death for Hooisers, and you might be surprised by what's on there.

We are all aware of how fragile life can be. It can be taken away at any given time. That's why it's so very important to not only take care of your body but to make every day count, because we aren't guaranteed tomorrow. There are several ways in which a person can pass away. The older I have gotten, the more I have realized that I'm not invincible. I know the things that run in my family history, and I'm lucky to have a wife who is very educated on how to take care of your body to prevent some of those things. Plus, now that I am a father, it gives me a new perspective on life, and it is also making me want to take the steps to take care of my body and take all the preventative measures I can when it comes to my health.

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Having said that, I was curious about the leading causes of death in Indiana. So, I went with the most definitive source I could find, which is the Centers for Disease Control. From what I can assess, it appears their list is based on the most recent fatality information regarding Indiana specifically. They have the ten leading causes of death for the state on there, and some of these might surprise you.

The Leading Causes of Death in Indiana

These can tend to change from time to time, and the leading causes of death in 2025 for Indiana are a little different from what they were in 2024. So, let's take a look at the top ten leading causes of death for Hoosiers in 2025 and see if any of these surprise you.

10. Chronic Liver Disease/Cirrhosis

Cirrhosis is a chronic liver disease where healthy liver tissue is replaced by scar tissue, ultimately impairing liver function. This is a late-stage complication of a variety of liver diseases, such as hepatitis viruses (B and C), alcohol abuse, and non-alcoholic fatty liver disease (NAFLD). While the damage is often irreversible, treatment focuses on slowing scar tissue buildup and managing complications.

9. Kidney Disease

The older I get, the more I hear about Kidney Disease among people. Sadly, it is also sometimes combined with cancer to form a deadly combination.

8.  Alzheimer’s Disease

This one hits close to home as I have known a few people to succumb to this illness. It's a long, sad goodbye that I hope I never have to experience with my loved ones again.

7. Diabetes

Another cause of death that hits close to home, as several of my family members have been diagnosed with it. My uncle even passed away as a result of his diabetes. It's just another reason to be mindful of what you put into your body and to always get your blood sugar checked.

6. Stroke

The more of these causes of death I see here, the more I realize how much they run in my family. Strokes can come out of nowhere. They can leave you partially paralyzed or worse.

5. Chronic Lower Respiratory Diseases

This is one that I am surprised to find as one of the leading causes of death in Indiana, because you don't hear much about these diseases compared to others. For those who aren't familiar, these diseases comprise of three major diseases, chronic bronchitis, emphysema, and asthma, which are all characterized by shortness of breath caused by airway obstruction. Then again, with the smoking rate, I shouldn't be too surprised.

4. COVID-19

We all know about COVID-19 and the pandemic it caused in 2020. While the pandemic is over, the virus is still making rounds with quite a few variants. Apparently, it's bad enough in Indiana to be one of the major causes of death for Hoosiers, even in 2025.

3. Accidents

There are no shortages of accident types that can lead to death. The main type of accident that we associate with leading to death is an automobile accident. So, please, be careful out there!

2. Cancer

I felt like this would be the number one leading cause of death in Indiana, honestly. With all the different types of cancer, there are, and how frequently you hear about people being diagnosed, it's important to get screened early.

1.  Heart Disease

This refers to several types of heart conditions. It can lead to heart failure and a heart attack. The latter of the two can kill you very quickly, sometimes instantly.

You can learn more about the leading causes of death in Indiana and check out the latest data by clicking here.